A higher post-HSCT non-relapse mortality rate occurred in patients treated with Besponsa (39%) than chemotherapy (23%). Nearly 6,000 people in the United States are likely to be diagnosed with the disease this year, and more than 1,400 are projected to die from it, according to estimates from the U.S. National Cancer Institute.
B-cell precursor ALL is an aggressive cancer in which an excess of B-cell lymphocytes are produced.
Inotuzumab ozogamicin is an antibody-drug conjugate comprised of a monoclonal antibody that targets CD22 - a cell surface antigen that is expressed on nearly all B-cell ALL cancer cells - linked to the cytotoxic agent calicheamicin. The trial measured the percentage of patients with no evidence of disease and full recovery of blood counts after treatment (complete remission or CR).
EU migrants can come to live in Britain after Brexit
An Irish Government spokesperson welcomed the imminent publication of the UK's Northern Ireland border policy document. London also said it wanted to uphold its freedom of movement agreement with Ireland , which predates the EU.
In testing that included 218 patients, 36 percent given Besponsa had their cancer vanish for eight months on average; 17 percent of those given chemotherapy had remission for a median five months. "These patients have few treatments available and today's approval provides a new, targeted treatment option".
"Based on the results seen in the INO-VATE ALL trial, Besponsa improved multiple efficacy measures, including rates of hematologic remission, MRD negativity, and stem cell transplantation", said lead study investigator Hagop M. Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, in a press release. Among patients achieving CR/CRi, those treated with Besponsa also demonstrated a higher rate of minimal residual disease (MRD) negativity (78% [95% CI: 68%-87%]) compared to those treated with chemotherapy (28% [95% CI: 14%-47%]).
Despite being an approvedmonotherapy for treating a rare type of leukemia among adults, patients are also warned of its side effects that include infection, anemia, hemorrhage, thrombocytopenia, neutropenia, leukopenia, pyrexia, febrile neutropenia, increased transaminases, increased gamma-glutamyltransferase, hyperbilirubinemia, fatigue, nausea, headache and abdominal pain.
Trump on Thursday again decried the removal of pro-slavery Civil War Confederacy monuments, which have fueled USA racial tensions. The pan-European FTSEurofirst 300 index lost 0.59 percent and MSCI's gauge of stocks across the globe shed 0.57 percent.
She performed Inspired at the "One Love Manchester" Benefit concert and recorded the song in her hometown of Nashville, TN. Most recently, Cyrus has been honoured with Variety's 2016 Power of Women award for all her philanthropic efforts.
La suspensión que existía sobre el balompié local continuará mientras que no sean aprobados los nuevos estatutos de la Fedefut . Si no acatan el procedimiento, la FIFA y Concacaf podrían establecer "sanciones adicionales" al futbol local.
Talking about shooting for the song, Sunny Leone says, "I have been working on it with Omung (Kumar ) sir and Ganesh sir". The much awaited song got released on 18th August and now has set trend list on fire on the internet.
I&W signs include the Pentagon canceling leaves for soldiers, sailors, marines, and airmen in the region; readying the U.S. He said President Trump "has told us to develop credible, viable military options, and that's exactly what we're doing ".
The smartphone has already been leaked gazillion time, and everyone has a fair share of the idea about the upcoming phone. The device was first updated two months ago and since then has been making it's presence over the benchmarking websites.
Andres Iniesta is one of the more surprising names on the 24-man shortlist for the Best FIFA Men's Player award for 2017. The victor of the award will be announced on the 23rd of October 2017 in London .
De acuerdo con el canal de televisión MTV3, la seguridad en el aeropuerto y las estaciones de tren de Helsinki ha sido reforzada. Además, advirtieron al público, a través de las redes sociales , a alejarse del centro de la ciudad.
Mumbai: On Wednesday, actress Riya Sen secretly tied the knot with her long time boyfriend Shivam Tewari in Pune. According to the media reports, Riya's wedding was a low-key affair and was attended by family and close friends.
"Son unos asesinos, simplemente unos criminales que no nos van a aterrorizar ", sostuvo el monarca en su cuenta de Twitter . Y convocaron a un minuto de silencio en toda España para demostrarle a los terroristas que no se les tiene miedo.
Sin embargo, Miguel Ángel Osorio Chong, Secretario de Gobernación, anunció que Protección Civil -cuyo Secretario, Fernado Lugo reportó que no había incidentes- activó los protocolos de seguridad para estos casos.
Así estará el tiempo este miércoles en Mendoza
La máxima será de 14 grados y los vientos soplarán del este con rachas que llegarán a los 44 kilómetros por hora. El Servicio Meteorológico Nacional (SMN) emitió un alerta para Neuquén y Río Negro por vientos fuertes.
Calories in popular foods must be cut, say health officials
We are delighted that the UCL Great Ormond Street Institute of Child Health will host the new Obesity Policy Research Unit (OPRU). She said companies were playing their part by making healthier options available and providing nutritional information on packs.
Union confirms more strike days for northern rail services
After a meeting with Northern bosses Mr Cash said the "responsibility for the inevitable disruption lies wholly with the company". Today it confirmed strike action starting Friday September 1 and finishing at the end of Monday September 4.
Uhuru leaves for Kagame's inauguration in Kigali
President Uhuru Kenyatta is Friday morning travelling to Kigali, Rwanda for the inauguration of President Paul Kagame. Prime Minister of São Tomé and Príncipe Patrice Emery Trovoada also arrived yesterday.
Several people stabbed in Finnish city of Turku
Finnish police said they have reinforced security at Helsinki Airport and train stations throughout the country. Witnesses report seeing at least one person lying motionless on the ground in the city center's market square.