Wawrinka, who has yet to drop a set in this year's tournament, won 6-3, 6-3, 6-1.
And Djokovic says he could take a break from the sport - ruling him out of Wimbledon later this month.
It's the first time a Canadian woman has won the mixed doubles title at Roland Garros. Nadal has now lost a combined eight games in his last three matches and just 22 games overall.
Since Djokovic defeated Andy Murray in last year's Roland Garros final, he suffered a third-round loss at Wimbledon.
Halep clinched the second set with a forehand victor and swept through the decider as Svitolina's spirit sagged, sealing victory with an ace. Pliskova will next play No. 3 Simona Halep of Romania.
"It's hard to comment, the third set", said Djokovic. I tried, I lost that crucial break at the beginning of the second and he started serving better. The Romanian wasted four set points but evened the match on her next opportunity in the tiebreaker after saving a match point.
Thiem showed why he is one of the most exciting young talents in the game, blasting 38 winners in a stunning 7-6 (7/5) 6-3 6-0 victory.
Austrian sixth seed Thiem is the only man to beat Nadal on clay this year - his Rome quarter-final success offsetting losses in the final in Barcelona and Madrid.
Ukrainian Svitolina saved four set points at 5-6 in the second and then had a match point in the tiebreak which Halep saved with a fearless backhand victor that kissed the sideline.
With the wind whipping at more than 15 miles per hour (25 kph), and the temperature in the low 50s (low teens Celsius), Djokovic was out of sorts in so many ways even before that 20-minute third set in which he won only 8 of 34 points.
Novak Djokovic'sFrench Open title defense is in real trouble.
"All in all, it was decided I think in the first set".
Since then, though, the highlight for Djokovic was a runner-up finish at the US Open. And Thiem then took the second set 6-3.
A year ago, Djokovic became the first man in almost a half-century to claim a fourth consecutive major championship and completed a career Grand Slam at Roland Garros.
The Djokovic-Thiem victor will face Rafael Nadal in the semifinals.
Nadal won 6-2, 2-0 after Carreno Busta withdrew with abdominal pain, in 51 minutes, reports Efe.
Novak Djokovic v Dominic Thiem - player profiles
Thiem has put in some scintillating displays at Roland Garros this year and, like Nadal has yet to drop a set at the tournament. However, a shock second round loss at the Australian Open to world number 117 Denis Istomin illustrated all the old failings.
Constand has testified that she felt she needed a lawyer to offer her advice, not necessarily to file a lawsuit. Bill Cosby has arrived at a suburban Philadelphia courthouse for the third day of his sexual assault trial.
UAE-based newspaper Gulf News and pan-Arab channel Al-Arabiya reported the crackdown on expressions of sympathy with Qatar. FlightRadar24, a popular airplane tracking website, said Qatar Airways flights already had started to be affected.
Glenview Capital Management LLC acquired a new stake in Tailored Brands during the fourth quarter valued at about $61,320,000. At Tailored Brands stock's average daily volume, it would take about eight sessions to buy back these bearish bets.
Estar cuatro meses sin jugar es complicado y la gente sabe que quiero mucho este club pero tengo q pensar en mi futuro también. Además, sobre su vínculo con el DT expresó que "mi relación con el entrenador ha sido mala esta temporada".
On Wednesday, he wouldn't rule out some time off. "It is a big challenge and I'm up for it". "It's the next chapter for me". For reference: Djokovic hasn't been shut out in a set at a Grand Slam since the 2005 U.S.
Opinions are the authors; not necessarily that of OANDA Corporation or any of its affiliates, subsidiaries, officers or directors. He has attacked journalists as " the enemy of the people", and urged that some be jailed for publishing classified information.
Trump says isolating Qatar could mark the "beginning of the end to the horror of terrorism" and backs Saudi Arabia and its allies. Foreign Minister Anwar Gargash said that Qatar had benefited from a mixture of "money and media and partisanship and extremism".
That settled Djokovic , who cruised through the second set and by the third was looking much more like his old self. It is the 11th time he has reached the quarterfinals at the French Open a record shared with Roger Federer .
He also stabbed another man, Micah Fletcher , 32, after he and the two others confronted him about what he was saying. SIEGEL: What do we know about the suspect in this case, about Christian? It was not clear if he had a lawyer yet.
That's a lot of responsibility on both ends and as a result he's not in the best position to affect the game positively. We play our game. "And we're not going to change just cause we're playing Golden State".
Putin spoke about Flynn in an interview conducted in Moscow on Friday with NBC's Megyn Kelly , which was broadcast Sunday night . Putin also shot down Kelly's one non-election related question about his reputation for killing journalists and dissidents.
Blake Shelton opens up about romance
Aside from his Twitter jokes, Shelton also took the stage to perform his hit single "Every Time I Hear The Song". "I picked a Blake Shelton song for my karaoke number", she told the crowd.
Judge rules IL not in compliance on Medicaid payments
The comptroller's office has said it scrambles each month to pay off an overall backlog of bills of more than $14 billion. Debt payments, pension contributions and distributions to local governments are required under state law.
Noticeable Buzzer: United States Steel Corporation (X)
Highline Capital Management L.P. bought a new position in United States Steel during the third quarter valued at about $4,215,000. Finally, Norges Bank acquired a new stake in shares of AK Steel Holding during the fourth quarter worth about $30,527,000.
Milky Way Exists In An Enormous Hole, Study Reveals
The filaments are made up of superclusters and clusters of galaxies, which in turn are composed of stars, gas, dust and planets. In the past, numbers measuring this rate of expansion - called the "Hubble Constant" - have been inconsistent.
Colorado teen dazzles US spccer team
Especially because now we have to win to climb the table in the top three, which will receive direct trips to Russian Federation . With that in mind, Arena plans to change personnel - and probably the formation and tactics, as well - ahead of the Mexico game.
Skywatcher alert: Strawberry 'mini moon' to make appearance
Residents of Qatar and the Arab region can see the "Pygmy full moon" with naked eye after it rises over the Doha sky at 6:16pm. Friday night is the ideal moment for skywatchers, as an interesting astronomical phenomenon will be visible from Earth.