In a statement on Twitter, Operation Inherent Resolve said: Coalition struck Syrian pro-regime forces advancing in a de-confliction zone near al Tanf posing a threat to U.S. partner forces.
The coalition has described Thursday's strike as a defensive action that does not change the USA policy of focusing military efforts on defeating ISIS.
A member of the US-backed Syrian rebel forces told Reuters the convoy comprised Syrian and Iranian-backed jihadists and was headed toward the Al-Tanf base when they clashed with some rebel forces.
BuzzFeed News is the first to have reported USA confirmation that it launched these new strikes.
According to ABC News, U.S. officials said several of the Syrian vehicles were destroyed in the strike.
Thursday's strike marks a noticeable shift on US policy in the country, which previously only primarily focused on going after jihadi groups such as the Islamic State, and not the Iran-Assad-Hezbollah-Shia militia coalition that is also operating in Syria.
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The region around Tanf, where the borders of Jordan, Syria and Iraq meet, has been considered a de-conflicted zone, under an agreement between the US and Russian Federation that went into effect earlier this month.
American aircraft struck a convoy of troops loyal to Syrian President Bashar al-Assad on Thursday, in a rare direct assault by the United States on forces affiliated with the Syrian government. Russian Federation tried multiple times to contact the Syrian forces, the official said.
The attack left eight of the fighters dead, the Syrian Observatory for Human Rights said.
The statement stressed that the Syrian army will continue the war on the terrorist groups and the US attack will not terrorize the army from continuing the battles on terrorism.
The US-led coalition commander first attempted to get the pro-Assad forces out of the zone by dispatching two US aircraft as "a show of force".
The strike by the anti-ISIL coalition came as the United Nations said Syria's government and rebels had agreed to set up expert committees to discuss "constitutional issues" at the latest round of UN-backed peace talks in Geneva.
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The airstrike occurred after a convoy of pro-Assad militia forces appeared to be headed toward at-Tanf, a town located near Syria's southeastern border with Iraq, according to the US official.
The U.S. military does not speak with the Syrian government.
The Special Forces are training the rebels to fight ISIS - and also accompanying them on combat missions against the militants.
"A convoy going down the road didn't respond to numerous ways for it to be warned off from getting too close to coalition forces in At-Tanf", an unnamed official told AFP.
Speaking to reporters, US Defence Secretary Jim Mattis said the US will defend its troops in case of "aggressive" steps against them.
The attorneys general cited Trump's own words, quoting him saying he was willing to let the health care law "explode". The litigation could become moot if Congress passes new health care legislation to replace the PPACA.
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May hopes the snap elections will boost the Conservatives' mandate for Brexit by increasing their parliamentary majority. Barnier said "we will defend the interests of the 27 (remaining) member states and the single market".
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Attacks have been recorded in at least 150 countries, including the UK, Russia, Ukraine, India, China, Italy, and Egypt. They handed me some papers which showed I was online at the time and chatting with my friends on the school network.
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Get great content delivered straight to your inbox every morning Monday-Friday at 8:00am, just a click away, Sign Up Now. More than 45 people filed claims to be Prince's wife, children, siblings or other relatives in the wake of his death.
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Browns sign Texas A&M's Myles Garrett, 1st overall pick
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Donald Trump to set up panel to investigate voter fraud
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In fact, the real reason hackers and criminals attack Windows is that it's the most popular desktop operating system in the world. Microsoft , for instance, ended support and the issuance of security patches for their operating system (OS) Windows XP in 2014.