Viernes, 20 Octubre, 2017

Reducing amino acids in diet can help treat cancer

Danilo Martir | 21 Abril, 2017, 00:39

SCOTS scientists have discovered that cutting out certain acids from the diet of mice can slow tumour growth and prolong survival, a development that could lead to clinical trials with cancer patients.

By working with genetically engineered mouse models of intestinal cancer (driven by Apc inactivation) or lymphoma (driven by Myc activation), the Cancer Research UK scientists hoped to extend diet therapy research to "more clinically relevant autochthonous tumors".

As chemo- and radiotherapy boost the levels of such reactive oxygen species, this also suggests that a diet depleted of these amino acids could make conventional cancer treatments more effective.

Professor Karen Vousden, Cancer Research UK's chief scientist and study co-author, said: "This kind of restricted diet would be a short-term measure and must be carefully controlled and monitored by doctors for safety". Our diet is complex and protein - the main source of all amino acids - is vital for our health and well-being.

She said the next step was to do clinical trials to see if a specialised diet without these amino acids was safe and helped slow tumour growth like it did in mice.

The study also found that the diet was less effective in tumors with an activated Kras gene, such as pancreatic cancer.

Detroit water department starts delinquent account shutoffs
The department in 2014 disconnected service to more than 30,000 customers due to unpaid bills, prompting protests over its actions.

Researchers said this could help to select which tumours could be best targeted by diet therapy.

Amino acids make up the building blocks of our proteins and are vital to cellular biosynthesis.

The researchers acknowledged that devising a diet without these two amino acids would be quite hard and they would test it on healthy people first to see how tolerable it was and "how easy it was to stick to and how it affects our levels of the two amino acids".

This is published unedited from the PTI feed.

Speaking to NutraIngredients, Dr Emma Smith, science information manager at Cancer Research UK, said: "I think this can be a really interesting angle".

"We'd also need to work out which patients are most likely to benefit, depending on the characteristics of their cancer".

Medio Ambiente y Salud advierten sobre problemas contaminación por Duquesa
Sólo en el 2015 indica la funcionaria, se reportaron 800 mil episodios de casos diarreicos agudos; 16 mil casos probables de dengue.

Cancer Research UK - which has been at the heart of the progress that has seen survival rates double in the last 40 years - wants to accelerate progress so that by 2034, three in four people will survive their cancer for at least a decade.

Additional details appeared April 19 in the journal Nature, in an article entitled "Modulating the Therapeutic Response of Tumours to Dietary Serine and Glycine Starvation".

This research was funded by Cancer Research UK and the European Research Council.

The charity spent more than £33 million in Scotland a year ago on some of the UK's leading scientific and clinical research.

Today, 2 in 4 people survive their cancer for at least 10 years.

Sunshine Heart Inc. (SSH) has current market capitalization of $2.84 Million
The stock's 52-week range is $0.90 - $48.60. 03/18/2015 - Sunshine Heart Inc had its " rating reiterated by analysts at Cowen. Highest potential price target is expected at $11.75 however minimum price target advised by analysts is $5.00.

Recommended

  • Williams Companies Inc (NYSE:WMB) & Corning Incorporated (NYSE:GLW) Traders Recap

    Corning Incorporated (NYSE: GLW ) share price decreased in the last trading session with a previous 52-week high of $28.36. Granite Investment Advisors Inc is a New Hampshire-based hedge fund with more than $535.32 million AUM in June, 2014.
    Apple's iconic glass cube on Fifth Ave to temporarily come down

    Apple's iconic glass cube on Fifth Ave to temporarily come down

    For its new renovation, the store will grow to more than double its current size, from 32,000 square feet to 77,000 square feet. Englewood, N.J. -based Waldorf Exteriors LLC is listed as the contractor for the project, which is valued at $2 million.

    Balacera dejó 4 muertos en vivienda cercana a colegio — Tumbes

    La persona que quedó herida en la matanza, ocurrida el último miércoles, falleció luego de varias horas de agonía. La policía custodia la vivienda de dos pisos y está a la espera de la llegada del fiscal de turno.
  • Rare two-man crew headed for International Space Station

    Fischer, on his first space voyage, and Yurchikhin floated into the waiting arms of station commander Peggy Whitson and her crew. EDT from the Baikonur Cosmodrome and take a six-hour, ten-minute ride to the Poisk module's docking port.

    Credit Suisse Group AG Reaffirms "Outperform" Rating for Amazon.com, Inc

    Cantor Fitzgerald reiterated an "overweight" rating on shares of Amazon.com in a report on Monday, April 10th. Shares of Amazon.com, Inc. (NASDAQ:AMZN) traded up 0.14% during mid-day trading on Thursday, hitting $900.48.

    Russia, US agree on joint work over Syria amid battered ties

    However, he added that he believed Moscow and Washington have "great potential" to improve their relationship. The Putin meeting with Tillerson began shortly after 6 pm local time, the U.S.
  • Man imprisoned 23 years in girlfriend's slaying is released

    Man imprisoned 23 years in girlfriend's slaying is released

    Even with the new developments, prosecutors fought to keep King's conviction, and a county judge refused to grant a new trial. Evin King's daughter Venus was just 13-years-old when her father went to prison for a murder he didn't commit.

    U.S. defense secretary looks to rebuild trust in Egypt visit

    On Thursday, the military announced it had killed a top IS cleric in Sinai air strikes, along with 18 other jihadists. The meeting was also attended by Egyptian Minister of Defense and Military Production Sedqi Sobhi, U.S.
    Mañana se realizará el primer simulacro nacional de sismo

    Mañana se realizará el primer simulacro nacional de sismo

    Son unas 105 mil instituciones educativas las que participarán en la actividad preventiva por casos de sismos y 150 mil docentes en apoyo de la actividad .
  • What was on display at yesterday's military march?

    Six-nation negotiations on dismantling North Korea's nuclear program in exchange for aid fell apart in early 2009. At the other end of the spectrum, they looked at the notion of accepting North Korea as a nuclear state.
    Draymond Green's Mom On The Viral And Hilarious Meme Of Her Son

    Draymond Green's Mom On The Viral And Hilarious Meme Of Her Son

    Payton likened the way Green changes the game to the way rim protectors have done in the past. "He can do it as a guard, and he can do it as a big man". "He changes the game like a big man, " Payton said ".
    Penguins vs. Blue Jackets: Game 4 prediction

    Penguins vs. Blue Jackets: Game 4 prediction

    It's miraculous how Pittsburgh manages to find guys like Conor Sheary and Jake Guentzel . "That boosted our play", Jenner said. The biggest save might have been a shot by Brandon Dubinsky that Fleury took off his mask seven minutes into the overtime.

US okays $295.6m military equipment sale to Iraq US okays $295.6m military equipment sale to Iraq America delivered $1.1 billion to the Iraqi military in 2014, and $1.7 billion in fiscal year 2015, according to the DSCA . State Department had approved a 295.6-million-U.S. -dollar worth of arms sale to Iraq.

Tillerson slams Iran as destabilizing force in Middle East He levelled the charge as the Trump administration launches a review of its policy towards Tehran. Even the nuclear deal's proponents have acknowledged that it has limitations.

Cayó una red de pedofilia que operaba por WhatsApp: 11 argentinos involucrados Cayó una red de pedofilia que operaba por WhatsApp: 11 argentinos involucrados Se registraron 39 detenidos y hay 135 personas identificadas en varios países, de las cuales 11 son argentinas. La investigación la inició en 2016 la Unidad de Investigación Tecnológica (UIT) de la Policía Nacional.

Trump to visit Philippines, Vietnam in November for regional summits: Pence The 31st ASEAN Summit and Related Meetings are slated on November 10-14 in Clark Field, Pampanga. Connelly wrote on Lowy Institute's Web site last March.

Clean energy to power Sound Transit trains beginning 2019 Clean energy to power Sound Transit trains beginning 2019 The agreement covers the span of light rail that is outside the Seattle city limits because that's where PSE operates. It was approved by the Washington Utilities and Transportation Commission on September 29, 2016.

Primeras fotos de la séptima temporada de 'Game of Thrones' Primeras fotos de la séptima temporada de 'Game of Thrones' Por ejemplo, a Cersei Lannister se le ve ocupando el Trono de Hierro , acompañada de su hermano y amante, Jaime Lannister . El 16 de julio se estrenará en todo el mundo la séptima temporada de "Game of Thrones", serie original de HBO .

Parupalli Kashyap, Harsheel Dani lose in pre-quarters of China Masters Parupalli Kashyap, Harsheel Dani lose in pre-quarters of China Masters He was once the highest ranked Indian men's singles player, but is now ranked 104. A while later, Dani - ranked 102 - lost to China's Sun 17-21, 18-21.

'Barb' de 'Stranger Things' no recomienda ver '13 reasons why' 'Barb' de 'Stranger Things' no recomienda ver '13 reasons why' La actriz de 19 años de edad, sorprendió a sus fans y seguidores de la exitosa serie al asegurar que es bisexual . Hace poco que salí del armario como bisexual para mi familia y amigos. "Soy muy, muy nueva en comunidad LGBT".

Obama: Phone call with French candidate wasn't an endorsement Obama: Phone call with French candidate wasn't an endorsement There are others running as well, but these are the candidates who appear to have the best chance of advancing to a runoff in May. Sarkozy said in a video message posted on Facebook - a rare foray into the campaign by him. "I'll hesitate to the end".

Audi Unveils E-tron Sportback Concept Car Audi Unveils E-tron Sportback Concept Car But the highlight of the prototype seems to be the fact that it's jam packed with light-emitting diodes. Dietmar Voggenreiter, Member of the Board of Management for Marketing and Sales at AUDI AG.

Trump's H-1B Executive Order Highlights Wisconsin Tech Worker Shortage The manufacturer of high-end tools and equipment employs approximately 11,500 people worldwide, according to its website. The trip to Wisconsin marked Trump's first visit to Speaker Paul Ryan's home state and district since taking office.

Riverbed To Acquire Xirrus To Boost SD-WAN And Cloud Networking Solutions Riverbed To Acquire Xirrus To Boost SD-WAN And Cloud Networking Solutions Earlier this year, Riverbed announced secure connectivity to Microsoft Azure and AWS using "one-click" technology. Riverbed Technology will acquire Xirrus in an effort to expand its SD-WAN solution.

Poland hoping for 'development of relations' between EU, Turkey after referendum Last year, Obama said there were trends in Turkey that he was "troubled with", including a fierce crackdown on the press. The "no" camp was led by main opposition CHP and supported by the HDP.

Pence visits youth baseball players in Japan President Donald Trump pulled the US out of the 12-country trade agreement after his inauguration in January. Last week, President Trump said he was sending an "armada" to the Korean Peninsula as a show of force.

Craig Shakespeare calls for Foxes to be streetwise against Atletico Madrid Craig Shakespeare calls for Foxes to be streetwise against Atletico Madrid Griezmann scored the penalty to give Atletico a 1-0 victory in Spain. Hosting Atletico Madrid will be a moment to savor for Leicester. Shakespeare said: "Wes looked better".